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¹ Kırıkkale Üniversitesi Veteriner Fakültesi İç Hastalıkları Anabilim Dalı, Kırıkkale - One of the most important factors for reducing the diarrhea related calf deaths is the application of appropriate fluid therapy. Treatments with antibacterial, antiparasitic or motilitating agents used in neonatal calf diarrhea, where fluid treatment is inadequate, can often be ineffective and resulted in calf loss. However, the fluid therapy is not as innocent as you think. The incidence of overhydrating-related pulmonary edema due to clinical findings such as dyspnea, tachypnea, tachycardia, as well as the incidence of complications due to false or excessive fluid, such as hypothermia, is higher than expected. In an ideal fluid therapy to be applied to diarrhea, the metabolic changes that have been occurred must be carefully interpreted to remove dehydration, electrolyte and acid-base imbalance, and meet daily requirements. For this purpose, determining which fluid to give, how much and how to give it is vital to the treatment. In this case, first of all, the decision is to determine which of the orally or parenterally fluid treatments is suspected. Some formulas have been developed for appropriate fluid therapy and laboratory data are needed to determine some parameters necessary for this. In field conditions, where the laboratory availability is limited, ideal fluid therapy can be applied using some form of clinical and clinical findings that can be used to determine the severity of dehydration, electrolyte and acid-base imbalance. Keywords : Calf, diarrhea, fluid therapy